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  • Title: Abdominal vagotomy does not block the satiety effect of bombesin in the rat.
    Author: Smith GP, Jerome C, Gibbs J.
    Journal: Peptides; 1981; 2(4):409-11. PubMed ID: 6276868.
    Abstract:
    Bombesin (2-16 microgram-kg-1, intraperitoneally) inhibited food intake in rats after abdominal vagotomy. Since the same vagotomized rats did not respond to the octapeptide of cholecystokinin (1-8 micrograms-kg-1, intraperitoneally), these data are decisive evidence (1) that bombesin does not produce satiety by releasing endogenous cholecystokinin and (2) that vagal afferents are not necessary for the satiety effect of bombesin.
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