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  • Title: Significant increases of cyclic AMP and alkaline phosphatase in bronchoalveolar lavage fluids of sheep exposed to asbestos.
    Author: Lemaire I, Nadeau D, Bégin R.
    Journal: Res Commun Chem Pathol Pharmacol; 1981 Sep; 33(3):567-70. PubMed ID: 6276951.
    Abstract:
    Exposure to asbestos for six months caused a significant increase of adenosine 3',5'-cyclic monophosphate (cAMP) levels (2-fold in bronchoalveolar lavage (BAL) fluids of sheep with no significant change in guanosine 3',5'-cyclic monophosphate (cGMP) and alkaline phosphatase (AP) activity. When exposure was prolonged for another 3 month-period, the increase in cAMP levels persisted and was accompanied by a 4-fold stimulation of AP activity, and enzyme associated with the surfactant fraction of BAL fluids.
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