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  • Title: Cardiac and hepatic effects of pre- and postnatal exposure to polybrominated biphenyls in rats.
    Author: McCormack KM, Stickney JL, Bonhaus DW, Hook JB.
    Journal: J Toxicol Environ Health; 1982 Jan; 9(1):13-26. PubMed ID: 6278154.
    Abstract:
    Body weight gain and hepatic concentrations of vitamin A were reduced in Sprague-Dawley rats by pre- and postnatal exposure to 100 ppm polybrominated biphenyls (PBBs). The ratio of liver weight to body weight, activity of hepatic delta-aminolevulinic acid (ALA) synthetase, and urinary excretion of uro- and coproporphyrins were increased by PBBs. Treatment with PBBs also increased the left atrial inotropic response to calcium. However, PBBs had no effect on development of the adrenergic neuronal transport system in heart, left atrial baselike peak tension, or inotropic response to ouabain. Thus PBBs retarded body weight gain and produced a variety of alterations in liver, but had little effect on cardiac contractile function.
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