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  • Title: The sequence of the nucleoprotein gene of human influenza A virus, strain A/NT/60/68.
    Author: Huddleston JA, Brownlee GG.
    Journal: Nucleic Acids Res; 1982 Feb 11; 10(3):1029-38. PubMed ID: 6278431.
    Abstract:
    The nucleotide sequence of the nucleoprotein gene of influenza A/NT/60/68 was established after using improved cloning methods to obtain full length cDNA clones in pBr322. The gene is 1565 residues long and codes for a basic protein of 498 amino acids. There are only 30 amino acid differences between it and the homologous sequence in A/PR/8/35, all occurring as point mutations. Assuming a common lineage, the evolutionary rate of divergence of the two strains is 0.18% amino acid per year. This confirms there is a slow but significant rate of evolution.
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