These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [An empirical combination of antibiotics used in aplasias during chemotherapy for acute malignant hemopathies (author's transl)].
    Author: Fiere D, Vuvan H, Guyotat D, Ffrench M, Gonnaud P, Extra JM, Imbert C, Coiffier B, Bryon PA, Rebattu P, Viala JJ.
    Journal: Sem Hop; 1982 Jan 21; 58(3):139-42. PubMed ID: 6278619.
    Abstract:
    Continuous infusion of amikacin, cotrimoxazole and carbenicillin was the second empirically established combination of antibiotics used when fever occurred during the induction phase of chemotherapy in sixty-five patients (58 acute myeloid leukemias, 5 acute lymphoid leukemias, 2 non Hodgkin lymphomas). Clinical evidence of infection was available in 25 cases and the infection was bacteriologically documented in 19 cases. Therapy was successful in 57 patients (89%). When infection was clinically or bacteriologically documented tha success rates were 92 and 82% respectively. The average length of treatment was ten days. In 25 patients receiving 2 g of amikacin in continuous infusion, the mean serum concentration was 15,9 micrograms/ml; in 17 patients receiving 3 g, the mean serum concentration was 19,4 micrograms/ml.
    [Abstract] [Full Text] [Related] [New Search]