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  • Title: [Sensitivity of hypothalamic neurons to beta-endomorphin, met-enkephalin, and thyroliberin].
    Author: Babichev VN, Mironov SF, Ignatkov VIa, Shvachkin IuP, Smirnova AP.
    Journal: Biull Eksp Biol Med; 1982 Feb; 93(2):33-5. PubMed ID: 6279210.
    Abstract:
    A study was made of susceptibility of hypothalamic neurons to beta-endorphine, thyroliberin and met-enkephalin applied microiontophoretically. The opioids were shown to exert a primarily unidirectional effect on the same neurons irrespective of the fact that the inhibitory action of beta-endorphine was more pronounced. The nalorphine-competitive antagonist of the opiates removed the met-enkephalin-induced inhibition. Unlike opioids, thyroliberin largely activated the test neurons. The possibility of neuropeptide participation in the control of gonadotropic function of the pituitary is discussed.
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