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  • Title: Disulfiram treatment of three patients with nickel dermatitis.
    Author: Christensen JD.
    Journal: Contact Dermatitis; 1982 Mar; 8(2):105-8. PubMed ID: 6279358.
    Abstract:
    Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg more than than twice a day readily cleared the eczema in three patients with severe and long-standing nickel contact dermatitis.
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