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  • Title: Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin.
    Author: Watanabe M, Nakase Y.
    Journal: Infect Immun; 1982 Mar; 35(3):1018-23. PubMed ID: 6279510.
    Abstract:
    Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test.
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