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  • Title: Separation of penicillin and its major degradation products by ion-pair reversed-phase high-pressure liquid chromatography.
    Author: Ghebre-Sellassie I, Hem SL, Knevel AM.
    Journal: J Pharm Sci; 1982 Mar; 71(3):351-3. PubMed ID: 6279818.
    Abstract:
    An ion-pair reversed-phase high-pressure liquid chromatographic technique capable of separating penicillin and its major degradation products within 8 min was developed. The influence of pH, counterion concentration, buffer concentration, and organic modifier content was studied and the observed behavior of the compounds during the chromatographic process was discussed.
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