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  • Title: Blocking of HLA and B lymphocyte alloantigens with F (ab')2 fragments of rabbit antibodies.
    Author: Billing RJ, Honig R, Peterson P, Safani M, Terasaki PI.
    Journal: J Immunol; 1976 Nov; 117(5 Pt.2):2040-2. PubMed ID: 62805.
    Abstract:
    F(ab')2 fragments of rabbit antibodies specific for human B lymphocytes will block human anti-B lymphocyte alloantibodies. F(ab')2 of anti-beta2m will block HLA alloantibodies. The F(ab')2 fragments can be used to improve the typing of B cell lines and certain leukemia cells which express both HLA and B lymphocyte alloantigens. Pretreatment of these cells with anti-beta2m F(ab')2 preparations allows the observation of B cell alloantigen reactions independently of HLA reactions. Similar use of rabbit anti-B cell F (ab')2 allows HLA reactions to be observed free from the "extra reactions" caused by B alloantibodies that are present in many HLA typing sera.
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