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  • Title: Experimental maedi virus infection in sheep: early cellular and humoral immune response following parenteral inoculation.
    Author: Larsen HJ, Hyllseth B, Krogsrud J.
    Journal: Am J Vet Res; 1982 Mar; 43(3):379-83. PubMed ID: 6280524.
    Abstract:
    The early immune response (19 weeks) in sheep inoculated parenterally with maedi virus was studied, using the lymphocyte transformation test, immunodiffusion test, complement-fixation test, and neutralization test. Cellular immune responses were detected between 3 and 7 weeks after the sheep were inoculated. Antibodies were detected by immunodiffusion test in 3 of 5 animals in weeks 7 to 11 and by complement-fixation test in weeks 15 to 19. Neutralizing antibodies were not detected. There was no sign of virus-induced immunosuppression as determined by lymphocyte responsiveness to mitogens or by in vivo and in vitro immune responses following BCG vaccination.
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