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  • Title: [Role of atypical sex cells in the histogenesis of germinative testicular tumors].
    Author: Romanenko AM, Persidskiĭ IuV.
    Journal: Arkh Patol; 1982; 44(2):22-8. PubMed ID: 6280647.
    Abstract:
    Histochemical and electron microscopic study of 23 germinative tumors of the testicle and organ tissue beyond the tumor was carried out. In 78% of the observations, normal seminiferous tubules were found to contain a special kind of cell elements, atypical sex cells (ASC), not observed in health. Ultrastructural and histochemical features of undifferentiated cells comprising seminoma and embryonal cancer were found to be similar to those of ASC and gonocytes of human embryo. The results suggest that ASC are the stem tumor cells for human germinative neoplasia which are characterized by single cytohistogenesis.
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