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  • Title: Plasmid DNA in the erythromycin producing microorganism, Streptomyces erythreus NRRL 2338.
    Author: Yi-guang W, Davies JE, Hutchinson CR.
    Journal: J Antibiot (Tokyo); 1982 Mar; 35(3):335-42. PubMed ID: 6281225.
    Abstract:
    Streptomyces erythreus NRRL 2338, the erythromycin producing microorganism, contains extrachromosomal (plasmid) DNA. Four different plasmids, pSE1, pSE2, pSE4 and pSE6 present in the wild-type strain have characteristic mobilities on agarose gel electrophoresis, molecular weight and restriction endonuclease digestion patterns. Treatment of the wild-type strain with ethidium bromide or acridine orange gave two variants, one that could not convert erythronolide B to 3 (alpha)-mycarosylerythronolide B and another than produced 2 approximately 3 times more erythromycin A than the parental strain. Although the plasmid DNA profile of these two variants is different from the wild-type strain, it is not possible to conclude that any of the structural genes for erythromycin biosynthesis are located on the plasmids of S. erythreus NRRL 2338.
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