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  • Title: In vitro stimulation of rabbit T lymphocytes by cells expressing herpes simplex antigens.
    Author: Kapoor AK, Ling NR, Nash AA, Bachan A, Wildy P.
    Journal: J Gen Virol; 1982 Apr; 59(Pt 2):415-9. PubMed ID: 6281376.
    Abstract:
    Lymphocyte stimulation responses to herpes antigens were studied using virus-infected X-irradiated cells. Rabbits were immunized with herpes simplex virus type 1 (strain HFEM) grown in RK 13 cells. For in vitro stimulation assay BHK21 cells were X-irradiated (15 000 rad) and infected with a high m.o.i. of a temperature-sensitive (ts) mutant (N102) of HFEM strain at the non-permissive temperature (38.5 degrees C) of virus. Virus antigens were expressed on the infected cells and there was no leakage of infectious virus into the medium at 38.5 degrees C. T lymphocytes from rabbits immunized with herpes simplex virus were specifically activated by herpesvirus-infected X-irradiated cells; lymph node cells from rabbits immunized with RK13 cells and from non-immune rabbits showed no proliferative response.
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