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  • Title: Dynorphin (1-13): analgesia, hypothermia, cross-tolerance with morphine and beta-endorphin.
    Author: Petrie EC, Tiffany ST, Baker TB, Dahl JL.
    Journal: Peptides; 1982; 3(1):41-7. PubMed ID: 6281745.
    Abstract:
    Intracerebroventricular administration of 20, 40 and 60 nmol of dynorphin (1-13) produced analgesia, as assessed by flinch/jump response to footshock, and hypothermia in the rat. Rats developed tolerance to both the analgesic and thermic effects of the 20 nmol dose of dynorphin. Dynorphin and beta-endorphin showed cross-tolerance with respect to their analgesic but not their thermic effects. Dynorphin and morphine also produced cross-tolerant analgesic effects. Naloxone (10 mg/kg, IP) completely blocked the barrel rolling produced by 20 nmol dynorphin but did not alter its analgesic or thermic effects.
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