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  • Title: Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs.
    Author: Labrie F, Veilleux R, Lefevre G, Coy DH, Sueiras-Diaz J, Schally AV.
    Journal: Science; 1982 May 28; 216(4549):1007-8. PubMed ID: 6281886.
    Abstract:
    The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3', 5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.
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