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  • Title: Impromidine-induced hypothermia in rats: effect of cimetidine and mianserine.
    Author: Nowak JZ.
    Journal: Agents Actions; 1982 Apr; 12(1-2):148-52. PubMed ID: 6282072.
    Abstract:
    Impromidine, a highly potent histamine H2-receptor agonist, given i.v. at doses of 3.1-62 nmole, induced a dose-dependent hypothermia in the rat with a maximal effect after 15 min. Cimetidine, an H2-receptor antagonist, having no effect when administered alone, antagonized the hypothermic action of impromidine. Two antiserotoninergic agents, p-chlorophenylalanine and metergoline, and chronic treatment with an antidepressant mianserine reduced the impromidine-induced hypothermia. It is suggested that the impromidine-induced hypothermia is an H2-receptor-mediated phenomenon, and the antagonizing effect of mianserine is related to serotonin receptor blocking activity of the drug rather than to its direct H2-receptor antagonism.
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