These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clinical pharmacology of cefotaxime in pediatric patients.
    Author: Kafetzis DA, Brater DC, Kanarios J, Sinaniotis CA, Papadatos CJ.
    Journal: Antimicrob Agents Chemother; 1981 Oct; 20(4):487-90. PubMed ID: 6282194.
    Abstract:
    Cefotaxime is a new cephalosporin with a spectrum of activity which may make it appropriate for use in pediatric patients. In 33 infants and children, administration of cefotaxime resulted in cure or improvement in 97% of patients, with eradication of 94% of isolated pathogens. Toxicity was minimal. The disposition of cefotaxime in this age group was similar to that reported for adults, with an elimination half-life of approximately 1.5 h, a volume of distribution of 1 liter/kg, a total serum clearance of 10 ml/min per kg, and a renal clearance of 6 ml/min per kg.
    [Abstract] [Full Text] [Related] [New Search]