These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Aspartate-induced changes in extracellular free calcium in 'in vitro' hippocampal slices of rats.
    Author: Marciani MG, Louvel J, Heinemann U.
    Journal: Brain Res; 1982 Apr 22; 238(1):272-7. PubMed ID: 6282396.
    Abstract:
    Extracellular free calcium ([Ca2+]0) and neuronal activity were measured with double-barreled Ca2+-selective/reference microelectrodes in the CA1 field of rat hippocampal slices during stimulation of Schaffer collaterals and during iontophoretic application of the excitatory amino acid aspartate (Asp). Baseline [Ca2+]0 was 1.5 mM. Repetitive stimulation and aspartate application caused decreases in [Ca2+]0 (delta Ca), which were largest in the pyramidal cell layer. During iontophoretic application of GABA, aspartate often failed to induce significant alterations in [Ca2+]0. Mg2+ (9 mM) and Ni2+ (3mM) when added to the perfusion medium reduced aspartate-dependent delta Ca by 15 and 70% respectively. In tetrodotoxin (10(-6) M) containing Ringer the aspartate-induced delta Ca were about 10% smaller. These findings suggest that the decreases in [Ca2+]0 are mainly due to a postsynaptic Ca2+ entry through selective Ca2+ conductances.
    [Abstract] [Full Text] [Related] [New Search]