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  • Title: The hypophyseal-adrenal axis in the protein-calorie malnourished rat.
    Author: Herbert DC, Carrillo AJ.
    Journal: Horm Metab Res; 1982 Apr; 14(4):205-7. PubMed ID: 6282725.
    Abstract:
    Male rats were fed an 8% low protein diet for 30 consecutive days beginning at 20 days of age. On day 50, the effect of the diet was evaluated on the hypophyseal-adrenal axis and the observations compared with those noted in age-matched controls fed a standard laboratory diet. The malnourished animals had significantly larger adrenal gland weights, relative to body size, and higher levels of serum corticosterone. Additionally, the number of ACTH-secreting cells in the pituitary glands of these rats was 63.8% greater than that present in the controls. These results suggest that ACTH secretion and adrenocortical physiology are stimulated under conditions of experimentally induced protein-calorie malnutrition.
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