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  • Title: Influence of dimercaprol on the early hepatic uptake of 111In-bleomycin in the BALB/c mouse.
    Author: Levine G, Sartiano GP, Boggs SS, Fried A, Gumerman LW.
    Journal: J Nucl Med; 1976 Dec; 17(12):1083-7. PubMed ID: 62831.
    Abstract:
    Dimercaprol (BAL) administered 1 hr before 111In-bleomycin in the normal BALB/c mouse produced an early preferential hepatic loading of 111In-bleomycin without a loading of the spleen, skin, bone, or muscle. Liver-to-muscle ratios were increased about threefold under the influence of BAL. Liver (c BAL)/liver (s BAL) ratios also increased threefold at 3 hr whereas relative muscle uptake remained at about unity. Indium-111 chloride (colloid, pH 6.5) used as a control did not show a similar increase. The findings suggest that the kinetics and distribution of 111In-bleomycin in the normal BALB/c mouse can be influenced by pretreatment with BAL.
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