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  • Title: Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary.
    Author: Proulx-Ferland L, Labrie F, Dumont D, Côté J, Coy DH, Sveiraf J.
    Journal: Science; 1982 Jul 02; 217(4554):62-3. PubMed ID: 6283632.
    Abstract:
    Administration of synthetic ovine corticotropin-releasing factor led to rapid, parallel increases in adrenocorticotropin and alpha-melanocyte-stimulating hormone concentrations in rat plasma. Prior treatment with dexamethasone almost completely blocked the adrenocorticotropin response but not the increase in melanocyte-stimulating hormone. These data demonstrate that corticotropin-releasing factor is a potent stimulator not only of adrenocorticotropin secretion from the corticotrophs of the anterior pituitary gland but also of peptide secretion from the intermediate lobe. Such data suggest that melanocyte-stimulating hormone and beta-endorphin play a role in the physiological response to stress.
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