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  • Title: Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells.
    Author: Paine AJ, Allen CM, Durkacz BW, Shall S.
    Journal: Biochem J; 1982 Feb 15; 202(2):551-3. PubMed ID: 6284133.
    Abstract:
    Rat hepatocytes cultured from 24h lose 60% of their NAD content. By using the differential response to inhibitors of the two major enzymes that catabolize NAD in mammalian cells, it is shown that poly(ADP-ribose) polymerase is responsible for the loss of NAD. The relevance of this observation to the use of cultured hepatocytes for the study of DNA repair induced by carcinogens is discussed.
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