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  • Title: Pharmacokinetics of ceftriaxone following intravenous administration of a 3 g dose.
    Author: McNamara PJ, Stoeckel K, Ziegler WH.
    Journal: Eur J Clin Pharmacol; 1982; 22(1):71-5. PubMed ID: 6284519.
    Abstract:
    The pharmacokinetic parameters of total (bound and unbound) and free (unbound) ceftriaxone in six healthy volunteers after intravenous injection of 39 were compared with low-dose data from a previous study. The dose-dependent behaviour of total drug was considerably more pronounced after the 3 gram dose. In contrast, total body clearance (C1FS = 258 ml/Min), renal clearance (C1FR = 170 ml/min) and volume of distribution (VFD (beta) = 168 1) of free (unbound) drug did not differ from the data reported earlier. There was no significant change in biological half-life (t1/2 (beta) = 7.8 h) or in the fraction excreted unchanged in urine (fu = 0.67).
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