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  • Title: [Biliary tract infections and antibiotics concentration of cefotiam in gallbladder tissue and bile (author's transl)].
    Author: Saito S, Yoshida M.
    Journal: Jpn J Antibiot; 1982 Apr; 35(4):1057-62. PubMed ID: 6285023.
    Abstract:
    In 12 patients undergoing operation, 1 g of cefotiam (CTM) was administered intravenously and CTM levels in gallbladder tissue and gallbladder bile were examined. CTM concentration in gallbladder bile was high in patients with patent cystic duct, while very low in those with cystic duct obstruction. CTM concentration in gallbladder tissue was low in patients with chronic inflammatory gallbladder. CTM activities of T-tube bile were compared with those of CMZ by cross over method in 2 cases. CTM showed extremely higher concentration in bile than CMZ. In a case with excessive output of bile, CTM activity, total bile acids concentration and canalicular flow/ductal flow ratio were low. It can be presumed that CTM was diluted by increased ductal secretion.
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