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  • Title: [Transportation of cefotiam from serum to cerebrospinal fluid (author's transl)].
    Author: Tokuriki Y, Takeuchi J, Handa H.
    Journal: Jpn J Antibiot; 1982 Apr; 35(4):1068-71. PubMed ID: 6285025.
    Abstract:
    Cefotiam (1 g) was administered by one-shot intravenous injection to the patients proceeding a brain surgery. The cerebrospinal fluid (CSF) and serum were taken as a specimen, and the concentration CTM was assayed by agar-well method using Proteus mirabilis ATCC 21100. The most high concentration of CTM was 2,273 micrograms/ml in serum, and 2.3 micrograms/ml in CSF, respectively. The concentration of CTM in serum, CSF, and CSF/serum ration were determined at the indicated time. It appears likely that CTM can pass into CSF more easily than other cephalosporins.
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