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  • Title: Acyclovir tolerance in humans.
    Author: Keeney RE, Kirk LE, Bridgen D.
    Journal: Am J Med; 1982 Jul 20; 73(1A):176-81. PubMed ID: 6285709.
    Abstract:
    Acyclovir tolerance has been explored in a broad range of human populations and dosage regimens with intravenous, topical, and oral formulations. Phase I pharmacokinetic/tolerance studies assured safety in special populations at unique risk of complicated herpes infections who were simultaneously at increased risk of toxicity to anti-DNA chemotherapeutic agents. Further safety evaluations accompanied placebo-controlled Phase II studies in infected patients who represent future users of acyclovir. These studies confirm acyclovir as the safest antiherpes agent to be explored in clinical studies to date.
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