These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Drug-resistant herpes simplex virus in vitro and after acyclovir treatment in an immunocompromised patient.
    Author: Schnipper LE, Crumpacker CS, Marlowe SI, Kowalsky P, Hershey BJ, Levin MJ.
    Journal: Am J Med; 1982 Jul 20; 73(1A):387-92. PubMed ID: 6285729.
    Abstract:
    An acyclovir-resistant herpes simplex virus (HSV) has been isolated from an immunocompromised patient during treatment for severe orofacial HSV infections with acyclovir. The resistant virus is deficient in expression of the HSV thymidine kinase (TK). Emergence of acyclovir resistance during clinical use appears to parallel the in vitro observations of selection for TK-deficient, acyclovir-resistant viruses following serial passage in the presence of the drug. The clinical importance of drug-resistant HSV in unclear, and further investigations are required to determine whether it will be an impediment to successful therapy of HSV infections.
    [Abstract] [Full Text] [Related] [New Search]