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  • Title: Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation.
    Author: Passaro E, Debas H, Oldendorf W, Yamada T.
    Journal: Brain Res; 1982 Jun 10; 241(2):335-40. PubMed ID: 6286044.
    Abstract:
    125I-Labeled cholecystokinin octapeptide ([125I]CCK-OP) diffuses rapidly by a non-carrier-mediated mechanism into the peripheral blood following injection into the lateral ventricle of a rabbit. In contrast, no [125I]CCK-OP was observed in the CSF following intravenous injection. This unidirectional free transport mechanism from CSF to blood may apply to other neuropeptides as well.
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