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  • Title: The proton translocating ATPase responsible for urinary acidification.
    Author: Gluck S, Kelly S, Al-Awqati Q.
    Journal: J Biol Chem; 1982 Aug 25; 257(16):9230-3. PubMed ID: 6286606.
    Abstract:
    H+ secretion by the turtle urinary bladder is produced by a proton pump located in the luminal membrane. We show that a microsomal fraction of these cells contains an electrogenic proton translocating ATPase that is inhibited by dicyclohexylcarbodiimide but not oligomycin or vanadate. On a sucrose density gradient, this ATPase co-migrated with luminal membranes labeled with concanavalin A, but was separate from a lysosomal marker. This enzyme is therefore the H+ ATPase that causes urinary acidification.
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