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  • Title: Inactivation of the Na permeability in squid giant axons.
    Author: Gillespie JI, Meves H.
    Journal: J Physiol (Paris); 1981 May; 77(9):1087-92. PubMed ID: 6286959.
    Abstract:
    Inactivation of the Na permeability has been studied in intact and perfused squid giant axons with the voltage clamp method. The main results are: 1. Upon depolarization inactivation develops along an exponential time course; the upper limit for an initial delay in the development of inactivation is 50-100 musec. 2. Adding 20-40 mM KCl to K-free external solution accelerates the development of inactivation and slows its removal. 3. Scorpion venoms increase the maintained conductance, i.e. make inactivation less complete; the voltage dependence of the maintained conductance is different from that of the peak conductance.
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