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  • Title: Specific protein-nucleic acid recognition in ribonuclease T1-2'-guanylic acid complex: an X-ray study.
    Author: Heinemann U, Saenger W.
    Journal: Nature; 1982 Sep 02; 299(5878):27-31. PubMed ID: 6287278.
    Abstract:
    RNase T1 is folded into an alpha-helix of 4.5 turns, covered by a four-strand antiparallel beta-sheet. Specific recognition of 2'-guanylic acid arises from hydrogen bonding between main chain peptide groups and the O-6 and N-1-H of guanine, as well as from stacking of Tyr 45 on guanine. At the active site, Glu 58, His 92 and Arg 77 are involved in phosphodiester hydrolysis.
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