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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions.
    Author: Singleton CK, Klysik J, Stirdivant SM, Wells RD.
    Journal: Nature; 1982 Sep 23; 299(5881):312-6. PubMed ID: 6287292.
    Abstract:
    In physiological ionic conditions (200 mM NaCl), the (dC-dG)16 and (dC-dG)13 blocks in plasmid pRW751 are in a left-handed state when the negative superhelical density of the plasmid is greater than 0.972. As the salt concentration decreases or when (dmC-dG) sequences are present, less negative supercoiling is required to induce the right- to left-handed DNA transition. Furthermore, the single strand-specific nuclease, S1, recognizes and cleaves aberrant structural features at the junction between neighbouring right- and left-handed DNA regions.
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