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  • Title: Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.
    Author: Brismar K, Werner S, Wetterberg L.
    Journal: Prog Clin Biol Res; 1982; 92():283-92. PubMed ID: 6287497.
    Abstract:
    Melatonin secretion is dependent both on the environmental lighting and noradrenergic control and seems to be related to the ACTH-cortisol secretion. The aim of the present study was to further elucidate the relationship between ACTH-cortisol and melatonin. For this purpose we chose the Metyrapone test. The melatonin secretion was studied in 10 patients, and increased significantly in 8/10 during and in one after the Metyrapone administration. These results further support a relationship between melatonin and ACTH-cortisol secretion, possibly through a suprapituitary interaction.
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