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  • Title: Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.
    Author: Tsuchida N, Ryder T, Ohtsubo E.
    Journal: Science; 1982 Sep 03; 217(4563):937-9. PubMed ID: 6287573.
    Abstract:
    The transforming protein of Kirsten murine sarcoma virus (Ki-MuSV) is a virally encoded 21-kilodalton protein called p21 kis. The sequences encoding p21 kis were genetically localized to a 1.3-kilobase segment near the 5' end of the viral genome by assaying the capacity of a series of defined deletion mutants of molecularly cloned Ki-MuSV DNA to induce focal transformation of mouse cells. Nucleotide sequencing of a portion of this region has led to the identification of an open reading frame of 567 nucleotides coding for p21 kis protein.
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