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  • Title: [Lactate dehydrogenase isoenzyme content of the tissue of a cancerous tumor and polyps of the large intestine].
    Author: Chernomordik AE.
    Journal: Vopr Onkol; 1982; 28(8):60-4. PubMed ID: 6287733.
    Abstract:
    Electrophoretic assays of LDH-isoenzymes in agar were carried out in 599 homogenates of bioptic and resected tissue material obtained from carcinoma (174), polyps (305) and grossly normal mucosa (120). A significant considerable increase in cathode fractions of LDh4 and LDH5 matched by a decrease in LDH1, LDH2 and LDH3 levels was observed in both tumor and polyp tissue. The degree of the changes varied greatly depending on patients' age, type of tumor and size of polyp. Preoperative telegamma therapy was followed by a significant decrease in LDH5 and an increase in LDH2 levels.
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