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  • Title: S-Adenosyl-L-methionine is a carbon donor in the conversion of benzo[alpha]pyrene to 6-hydroxymethylbenzo[alpha]pyrene by rat liver S-9.
    Author: Flesher JW, Stansbury KH, Sydnor KL.
    Journal: Cancer Lett; 1982; 16(1):91-4. PubMed ID: 6288234.
    Abstract:
    In earlier studies we reported that 6-hydroxymethylbenzo[alpha]pyrene is a metabolite of benzo[alpha]pyrene and of 6-methylbenzo[alpha]pyrene when these substrates are incubated with homogenates or microsomal preparations of liver and microsomal preparations of subcutaneous tissue from Sprague--Dawley rats. However, the origin of the carbon donor was not established. We now report that S-adenosyl-L-methionine (SAM) can serve as a carbon donor in the metabolic formation of 6-hydroxymethylbenzo[alpha]pyrene from benzo[alpha]pyrene by the S-9 fraction of rat liver.
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