These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Chemical carcinogen activation in the rat mammary gland: intra-organ cell specificity.
    Author: Gould MN.
    Journal: Carcinogenesis; 1982; 3(6):667-9. PubMed ID: 6288281.
    Abstract:
    Cells from 50-55 day old virgin Sprague-Dawley female rat mammary gland were divided into parenchymal (epithelial) and stromal enriched populations. The ability of these cells to activate carcinogens was quantitated employing a mediated mutagenesis assay. In addition, the populations' ability to produce water soluble metabolites from these carcinogens was estimated. We report that the potent mammary carcinogen 7,12-dimethylbenz[a]anthracene was activated by both mammary parenchymal and stromal cells, while the non-mammary carcinogen aflatoxin B1 was not activated by either cell type. However, the weak mammary carcinogen benzo[a]pyrene was activated by the stromal cells and not by the parenchymal cells from which mammary carcinomas arise. The data suggest that the intra-organ relationship between cell types that activate a carcinogen, and cell types that undergo neoplastic transformation, may in part help explain the organ specific potency of a carcinogen.
    [Abstract] [Full Text] [Related] [New Search]