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  • Title: Influence of sulpiride-induced hyperprolactinemia on baboon menstrual cycles: a longitudinal study.
    Author: Aso T, Matsuoka M, Su J, Horie K, Taii S, Motohashi T, Nishimura T.
    Journal: J Med Primatol; 1982; 11(1):20-34. PubMed ID: 6288953.
    Abstract:
    The influence of sulpiride-induced hyperprolactinemia on the hypothalamic-pituitary-ovarian function of the baboon (Papio cynocephalus) was investigated. Plasma levels of prolactin, LH, FSH, estrone, estradiol, 17-hydroxyprogesterone, progesterone and 20 alpha-dihydroprogesterone in control and consecutive treatment cycles (sulpiride i.m. injections 100 mg/day) were determined serially. The hormonal changes indicate that the ovary is the most sensitive site to the direct inhibitory action of sulpiride-induced hyperprolactinemia.
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