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  • Title: Pharmacokinetics of ceftizoxime in patients undergoing hemodialysis.
    Author: Shah PM, Knobloch M, Haag R, Kühnle HF.
    Journal: Methods Find Exp Clin Pharmacol; 1982; 4(3):185-8. PubMed ID: 6289027.
    Abstract:
    Serum pharmacokinetics of 1 g ceftizoxime were studied in eight patients undergoing chronic haemodialysis. Arterial blood samples were collected at 3, 60, 120, 180 and 240 minutes and before the next dialysis 2-3 days after injection of ceftizoxime. Three minutes after injection the serum levels were 122 +/- 8.4 microgram/ml and 19.4 +/- 1.7 microgram/ml at the end of the dialysis. Mean elimination half-life under haemodialysis was 2.1 hours. Serum concentrations ranged from 4.9 to 13 microgram/ml two to three days after the haemodialysis.
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