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  • Title: Stimulatory effect of pertussis toxin on tissue cyclic AMP levels in canine thyroid slices.
    Author: Katori A, Yamashita K.
    Journal: Endocrinol Jpn; 1982 Apr; 29(2):261-3. PubMed ID: 6290206.
    Abstract:
    The in vitro effects of the protein purified from the culture medium of Bordetella pertussis (pertussis toxin) on cyclic AMP levels in canine thyroid slices were studied. The toxin caused a three-fold increase in tissue cyclic AMP levels after 18 h or longer incubation. Furthermore, when the slices were incubated with the toxin for 6 h and then incubated without the toxin for further 12 h, similar effects were observed. These results indicate that pertussis toxin elevates tissue cyclic AMP levels after a time lag in a manner different from other thyroid stimulators.
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