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  • Title: VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas.
    Author: Oliva D, Nicosia S, Spada A, Giannattasio G.
    Journal: Eur J Pharmacol; 1982 Sep 10; 83(1-2):101-5. PubMed ID: 6290240.
    Abstract:
    The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of hormone release from adenoma fragments (90-247% at 10-7 M VIP) and of cAMP formation in membrane preparations (75-140% at 3 X 10-6 M VIP). Therefore a role of VIP in the control of ACTH secretion in human ACTH-secreting adenomas is suggested; a cAMP-dependent mechanism of action can also be hypothesized.
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