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  • Title: [Transfer of cefotiam into the tissues of gynecological organs].
    Author: Tateno M, Shitano T, Hayashi Y, Nakasone K.
    Journal: Jpn J Antibiot; 1982 May; 35(5):1127-30. PubMed ID: 6290695.
    Abstract:
    Uterine infections, particularly myometritis have been shown to be severe because of the difficult passage of the antibiotics into the affected tissues. Consequently, a biochemically novel drug, cefotiam (CTM) was investigated for the distribution into the uterine body, uterine cervix, ovary and oviduct of 10 patients with benign tumor, 1 g of CTM in 250 ml of 5% glucose was infused for 2 hours. The mean concentration of the antibiotics in the serum, uterine body, uterine cervix, ovary and oviduct at 30 minutes after the intravenous drip infusion was, respectively 19.7 micrograms/ml, 10.1 micrograms/g, 12.9 micrograms/g, 10.7 micrograms/g and 11.7 micrograms/g. The concentration ratio of the tissue to serum was found to be relatively high (51.5--65.5%), as compared to other antibiotics. In this experiments, no adverse effects, such as laboratory findings were found.
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