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  • Title: [Clinical evaluation of cefotiam chloride in the surgical field, with special reference to its intrathoracic distribution and prevention of postoperative infections following thoracic surgery].
    Author: Imaizumi M, Kawahara K, Akiyama S, Kimura J, Kondo T.
    Journal: Jpn J Antibiot; 1982 May; 35(5):1145-52. PubMed ID: 6290698.
    Abstract:
    There are few report about the concentration of antibiotics in the tissue of intrathoracic organs. At present, it was analized the concentration in serum and tissue of intrathoracic organ and urinary excretion for CTM, and clinical effect against postoperative infection and side effect of CTM were discussed. 1) The peak concentration in serum was 48.7 micrograms/ml and half lives of CTM was about 30 minutes in 1 hour drip infusion of CTM 1g. 2) The concentration of CTM in lung tissue was about 30--50% of serum level. The concentration of CTM to pulmonary lesion was relatively high. 3) The concentration of CTM to the secretion of normal bronchiole was high as well. 4) The concentration of CTM to the bone marrow of rib was less than lung tissue. 5) Urinary excretion of CTM was 50--77% of total dose by 6 hours after injection. 6) CTM has wide spectrum and is useful to prophylaxis of postoperative infection. 7) It may be ineffective for Pseudomonas aeruginosa infection of lung.
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