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  • Title: Adenosine actions and adenosine receptors after 1 week treatment with caffeine.
    Author: Fredholm BB.
    Journal: Acta Physiol Scand; 1982 Jun; 115(2):283-6. PubMed ID: 6291335.
    Abstract:
    After one week treatment with caffeine (20 mg/kg i.p.) the number of adenosine receptors, as determined by specific binding of (3H)-L-PIA, in rat cerebral cortical membranes was increased by about 25%. Cyclic AMP accumulation induced by adenosine analogues in slices of rat hippocampus was unaffected by caffeine treatment. The inhibition of lipolysis in rat fat cells by 2-chloro-adenosine was similarly unaffected. The potency of caffeine as an antagonist of these adenosine-receptor mediated effects was not altered by caffeine treatment. It is concluded that at least some adenosine receptors are up-regulated as a consequence of prolonged caffeine treatment, but that the increase in receptor number is not related to changes in at least two effects of adenosine and caffeine.
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