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  • Title: [Mechanism of polyene antibiotic inactivation. Changes in the physicochemical characteristics and the destruction of the polyene chromophore levorin during inactivation].
    Author: Bronov LV, Kroshilova TM, Slonim VZ, Ivanov GG, Komarov EV.
    Journal: Antibiotiki; 1982; 27(7):496-501. PubMed ID: 6291449.
    Abstract:
    The results of studying free radicals of some polyenic antibiotics with the EPR method are presented. It is shown that the number of free radicals increased by 100 per cent with a 2-fold decrease in the biological activity. A qualitative change in the EPR spectrum due to the presence of a new radical type was also observed. The changes in the spectral characteristics of levorin allowed one to demonstrate that breaking of the links and formation of the polymer products during oxidative destruction of the polyenic chromophore resulted from attachment of the radicals through the antibiotic double bonds. The data correlate with the results of the quantum-chemical evaluation of the polyenic chromophore.
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