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  • Title: Degradation of glucagon receptors by dispase treatment of isolated intact rat hepatocytes.
    Author: Pingoud V, Haas T, Trautschold I.
    Journal: Biochim Biophys Acta; 1982 Oct 11; 721(2):218-22. PubMed ID: 6291629.
    Abstract:
    Collagenase-isolated rat hepatocytes were treated with dispase II, a neutral proteolytic enzyme which is often used for the disintegration of neonatal cells. The treatment of hepatocytes with dispase II caused a significant reduction of glucagon binding to the intact cells. The deleterious effect of this enzyme on the specific glucagon binding site is accompanied by a reduction of the maximum intracellular cyclic AMP production.
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