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  • Title: Blockade of ganglionic transmission during synaptogenesis decreases alpha-bungarotoxin binding in the chick ciliary ganglion and iris.
    Author: Chiappinelli VA.
    Journal: Brain Res; 1982 Sep; 281(1):118-21. PubMed ID: 6291725.
    Abstract:
    The role of normal synaptic activity in the biochemical development of the nervous system has been examined in the chick embryo. Chlorisondamine, a ganglionic blocking drug, was administered in ovo during the period of synaptogenesis in the parasympathetic ciliary ganglion. Following treatment with chlorisondamine, nicotinic binding sites (as measured with [125I] alpha-bungarotoxin) were significantly reduced in both the ganglion and its end organ, the striated iris muscle. While the number of [125I] alpha-bungarotoxin binding sites eventually approached control levels in the iris, binding in the ciliary ganglion remained below normal values through hatching.
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