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  • Title: Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators.
    Author: Fong S, Vaughan JH, Carson DA.
    Journal: J Immunol; 1983 Jan; 130(1):162-4. PubMed ID: 6292300.
    Abstract:
    The subsets of human peripheral blood B lymphocytes from which Epstein Barr virus- (EBV) and pokeweed mitogen- (PWM) induced IgM anti-IgG autoantibody-producing B cells arise have been compared. EBV-induced IgM anti-IgG autoantibodies preferentially derive from a subset of B cells that forms rosettes with mouse erythrocytes. In contrast, PWM-induced IgM anti-IgG antibodies preferentially arise from a B cell subset lacking the mouse erythrocyte receptor.
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