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  • Title: Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance.
    Author: Muller RU, Andersen OS.
    Journal: J Gen Physiol; 1982 Sep; 80(3):427-49. PubMed ID: 6292331.
    Abstract:
    The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage-dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels.
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